Africa confronts escalating health crises including over 308,935 cholera cases and 7,131 deaths in 2025 up sharply from prior years with South Sudan, Sudan, DRC, Angola, and Nigeria accounting for 88% of infections; Angola alone reported 34,000 cases and 877 fatalities. Mpox exploded to 132,008 suspected and 40,138 confirmed cases, doubling 2024 figures, though Sierra Leone achieved 99% decline; new cases hit Mali while 4.8 million vaccine doses reached 16 countries, vaccinating 1.9 million.
Viral haemorrhagic fevers persist: Ethiopia manages Marburg outbreak (12 cases, 7 deaths), DRC's Ebola nears closure after no cases since September, and Namibia reported fatal Crimean-Congo fever. Africa CDC secured $234 million (47% of Pandemic Fund allocations) plus $40 million for surveillance in high-risk nations like Senegal and Malawi, praising AHSS agenda alignment amid workforce shortages only half the needed 2 million community health workers.
Incident manager Yap Boum called Africa a "high-threat environment," urging scaled surveillance, CHW expansion, and partner coordination against climate-driven outbreaks, poor WASH, and infrastructure strains.